Diagnostic value of antineutrophil cytoplasmic antibodies and anti- Saccharomyces cerevisiae antibody in Iranian patients with inflammatory bowel disease
| Journal | Volume 72 - 2009 |
| Issue | Fasc.3 - Original articles |
| Author(s) | Ali Bahari, Mahmoud Aarabi, Mohsen Aarabi, Mehdi Hedayati, Ali Jarollahi, Farzad Firouzi, Rahim Aghazadeh, Mohammad Reza Zali, Mohammad Hashemi |
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| (1) Department of Gastroenterology, (6) Dept. of Clinical Biochemistry, School of Medicine, (7) Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran ; (2) Department of Inflammatory Bowel Disease, Research Center of Gastroenterology and Liver Diseases, Tehran, Iran ; (3) Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, UK ; (4) Clinical Laboratory, Research Center for Endocrinology and Metabolic Diseases, Tehran, Iran ; (5) Clinical Pathology Laboratory, Mofid Children Hospital, Tehran, Iran. *Both authors share senior authorship. |
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Background and study aims : Perinuclear antineutrophil cyto- plasmic autoantibodies (pANCA) and anti-Saccharomyces Cerevisiae antibody (ASCA) are potential markers for diagnosis of inflammatory bowel disease (IBD). The aim of the present study was to evaluate the diagnostic value of pANCA and ASCA in Iranian patients with IBD. Patients and Methods: Serum samples were collected from 144patients with IBD (113 ulcerative colitis and 31 Crohn's disease) and patients with non-IBD problems were assayed for ASCA by Enzyme-Linked Immunosorbent Assay (ELISA) and for pANCA by indirect immunofluorescence assay. Results : Sensitivity and specificity of pANCA in UC were 39.8% and 82.1%, respectively. For CD, pASCA test provided the sensitivity of 58% and specificity of 70%. A combination of pANCA+/ASCA- for diagnosis of UC showed a sensitivity of 31.9% and specificity of 89.1%. In addition the combination of pANCA-/ASCA+ showed a sensitivity of 35.5% and specificity of 79.8% for diagnosis of CD. Conclusion : Due to low sensitivity of pANCA and ASCA alone or in combination, they are not valuable serological markers for diagnosis of UC or CD. (Acta gastroenterol. belg., 2009, 72, 301-305). |
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© Acta Gastro-Enterologica Belgica. PMID 19902862 |
